Blog by Jaydev Varsani | Clinical Pharmacist at Murrays Chemist

Medications like Wegovy (semaglutide) and Mounjaro (tirzepatide) have transformed the way we approach weight loss and type 2 diabetes. As effective as these GLP-1 and GIP receptor agonists are, it’s important that patients are made aware of potential side effects, including those involving the gallbladder.

At Murrays Chemist, our goal is to ensure every patient receives safe, personalised care, and that includes understanding how to reduce the risk of complications like gallstones during treatment.

How Do Wegovy and Mounjaro Work?

Wegovy and Mounjaro are part of a class of medications that mimic natural gut hormones like GLP-1 and GIP. These hormones help:

• Suppress appetite

• Delay stomach emptying

• Improve glucose control

• Promote significant weight loss

Because these medications help patients lose weight quickly, they can alter how the gallbladder empties, which is where some of the concern lies.

Do These Medications Increase Gallstone Risk?

Research and real-world evidence suggest that GLP-1 and GIP agonists may increase the risk of:

• Gallstones (cholelithiasis)

• Gallbladder inflammation (cholecystitis)

The issue isn’t necessarily the medication itself, but rather the rapid weight loss it can trigger. Quick and significant fat loss—no matter the method—can lead to slower bile flow, which makes it easier for stones to form.

Wegovy vs Mounjaro: Any Differences in Risk?

At present, there’s no definitive data suggesting a major difference in gallbladder risk between Wegovy and Mounjaro.

That said, Mounjaro (tirzepatide), as a dual GLP-1 and GIP agonist, has been shown in clinical trials to achieve greater weight loss in some patients compared to semaglutide (Wegovy). With more pronounced weight loss, the gallstone risk may be slightly higher, especially if lifestyle support isn’t in place. Regardless of the medication, proper guidance and monitoring are key.

Recognising Gallstone Symptoms

It’s important to know the signs of gallbladder issues while on these medications. If you’re on Wegovy or Mounjaro, keep an eye out for:

• Pain in the upper right abdomen (often triggered by eating, especially fatty meals)

• Pain radiating to the back or right shoulder blade

• Nausea or vomiting

• Bloating or indigestion

• Fever or chills (in cases of infection)

• Jaundice (yellowing of the skin or eyes)

These symptoms can be intermittent or come on suddenly. If you experience any of them, it’s important to seek medical advice straight away.

More information on gallstones can be found on the NHS website.

How to Lower Your Gallbladder Risk on Wegovy or Mounjaro

Fortunately, you can take simple steps to reduce your chances of developing gallstones:

1. Lose Weight Gradually
Aim for no more than 1–2 lbs per week. Avoid crash diets or overly aggressive calorie restriction.

2. Stay Well Hydrated
Water helps keep bile flowing and prevents it from becoming concentrated and sludgy.

3. Eat Regularly
Skipping meals can cause bile to sit in the gallbladder longer, increasing stone risk. Stick to small, regular meals.

4. Include Healthy Fats
Moderate amounts of fats—like those in olive oil, nuts, or oily fish—stimulate the gallbladder to empty more effectively.

5. Monitor Symptoms
Track how you feel after meals and during your treatment. Any changes in digestion or new pain should be reported promptly.

How Murrays Chemist Supports Your Weight Loss Journey

At Murrays Chemist, we go beyond simply dispensing injections. Our private weight management clinic is led by a clinical prescribing pharmacist and includes:

• Face-to-face monthly reviews

• Tailored diet and lifestyle support

• Medication safety monitoring

• On-demand consultations for side effects

• Optional private blood testing

We’re proud to offer a holistic, South Asian-friendly approach that’s helped hundreds of patients achieve lasting weight loss safely.

Visit Novo Nordisk UK to learn more about Wegovy.

Visit Eli Lilly UK to learn more about Mounjaro.

Final Thoughts

Gallbladder complications from GLP-1 and GIP receptor agonists are relatively uncommon—but they can happen, especially during rapid weight loss. With the right support, education, and monitoring, these risks can be managed effectively.

At Murrays Chemist, we offer trusted, pharmacist-led care to ensure you get the most from your treatment—without unnecessary side effects.

Ready to Take the Next Step?

Our weight loss injection programme is open to new patients. Whether you’re starting treatment or already on it and want better, more personal support, we’re here to help.

Book your face-to-face consultation with our experienced clinical team and let’s work together to help you reach your goals—safely, sustainably, and with confidence.